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Here's what makes this topic more complex than a simple yes-or-no answer: 5-Amino-1MQ functions as a non-competitive inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide into N-methyl nicotinamide

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In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 μg vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)