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Expression of GFAP is markedly upregulated after nerve injury and remains elevated for several weeks to months 264,265

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The absence of tissue growth effects also means AOD-9604 avoids many common side effects of growth hormone therapy including joint pain and swelling from connective tissue proliferation, carpal tunnel syndrome from tissue expansion, edema and fluid retention from protein synthesis and sodium retention, and concerns about growth-promoting effects in individuals with tumor history