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injections of doses of 20, 100, or 500 μg/kg to rats, the peak time (Tmax) of each dose was 3 min, while the Cmax of each dose was equivalent to 12.3, 48.9, and 141 ng/mL, respectively

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Options to purchase 0.2 million, 1.6 million, and 1.8 million shares of common stock were outstanding at December 31, 2003, 2002 and 2001, respectively, but were not included in the computation of diluted earnings per share because the options’ exercise prices were greater than the average market price of the common stock