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acnes can stimulate adaptive immune responses by inducing the secretion of pro-inflammatory cytokines (Moreno-Arrones and Boixeda, 2016), such as IFN-γ and IL-17A, from Th1 and Th17 lymphocytes through Toll-like receptors (TLRs) (Ozlu et al., 2016), activation of inflammasomes (Moreno-Arrones and Boixeda, 2016), induction of matrix metalloproteinases (MMPs) ( C
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