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These findings underscore the intricate relationship between Hcy and lipid metabolism dysregulation, shedding light on potential mechanisms underlying adipose tissue dysfunction and its implications for cardiovascular health

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NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1