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In summary, the BDNF-mimetic PA nanostructure produced an extremely bioactive matrix that could activate the TrkB receptor and its subsequent signaling cascades, which was necessary for cell viability, development, and functional maturation in 2D cultures, and could stimulate neuron infiltration in 3D while boosting maturity and functional electrical activity, which aided in the promotion of the regeneration or integration of transplanted cells in the CNS (Nam et al., 2020