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Potential risks include: Infection risk – if injections are administered in non-clinical settings without appropriate sterile technique Allergic reactions – to any component of the formulation Liver toxicity – theoretical concern with excessive methionine or choline Drug interactions – particularly if combined with other supplements or medications Unknown long-term effects – due to absence of longitudinal safety data The MHRA advises caution with unlicensed injectable products, as quality, purity, and sterility cannot be guaranteed

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These studies laid the foundation for considering the POA as a central site of thermoregulatory control