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In fact, the design benefit of such heteromultivalent decorations in augmenting the biofunctional output of synthetic particles has also been demonstrated in other areas of biomaterials research, for example, mechanistic studies of leukocyte rolling and adhesion conducted by Hammer and Eniola‐Adefeso laboratories utilizing polystyrene particles co‐decorated with selectin‐binding and ICAM‐1‐binding ligands, targeting of nanoparticles to activated endothelium via combination binding of E‐selectin and VCAM‐1 conducted by Auguste laboratory, and research conducted in our laboratory on combination targeting of multiple receptors on platelets and “platelets + fibrin” for enhancing nanoparticle targeting in vascular drug delivery
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