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the level of peripheral adaptive immune cells changes dynamically after the onset of IS, and changes in Tregs correlate with IS severity and prognosis (Weitbrecht et al., 2021)

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This was shown in HEK 293 cells, known to have voltage-gated K + [272,273], Na + [274], and Ca 2+ [275] channels, and with different local anesthetics applications (i.e., bupivacaine [89], lidocaine [60], tetracaine [276], and oxibuprocaine [276])