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Similar to nucleated cells, the intracellular Ca 2+ concentration of erythrocytes is kept in the low nM range [74], whereas the extracellular Ca 2+ is orders of magnitude larger (low mM range)
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Koselugo (selumetinib) is just the first step, with many more drugs in the pipeline for all manifestations of NF, which need funding to be tested in preclinical and clinical trials
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