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Triptans act on the serotonin receptors (5-HT1B) in the blood vessels of the brain, constricting them and inhibiting the release of neuropeptides.[ref] Genetic studies show a link between migraine susceptibility and a type of genetic variant known as a variable number tandem repeat in a serotonin transporter gene.[ref] Using PET scans on people who had been migraine-free for at least 48 hours, researchers can study the 5-HT1B (serotonin) receptor in the brain