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If the goal is long-term hippocampal neurogenesis or recovery from cognitive impairment models (such as scopolamine-induced amnesia), higher cumulative exposure via repeated dosing at moderate levels (0.5–1.0 mg/kg daily for 7–14 days) yields more robust outcomes

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In a prospective study of 38 female CFS patients, 2 months of multivitamin-mineral supplementation resulted in increased SOD activity with concomitant alleviation of fatigue, sleep disturbances, autonomic symptoms, and headache burden [131]