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In the central nervous system (CNS), P300 and its homologous protein CBP participate in the physiological processes of various diseases by mediating histone and non-histone lactylation

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Importantly, pentadecapeptide BPC 157 was more active than recombinant human platelet-derived growth factor (PDGF-BB), stimulating both expression of early growth response 1 (egr-1) gene and its repressor nerve growth factor 1-A binding protein-2 (NAB2) (18)