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Thus, it may be speculated that besides a role in the activation of GDH to favor glutamine anaplerosis (Li et al., 2010) and fat oxidation inhibition causing the accumulation of LC-CoA or acyl-carntine compounds (Pepin et al., 2010), HADH/SCHAD mutations causing hyperinsulinemia also implicates the PEP cycle (Figure 6)
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