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Although this phase I–II trial along with the other small-scale clinical studies described earlier neither proved nor disproved the value of high-dose vitamin C in cancer therapy, it did provide practical information and indicate a feasible way to evaluate this plausible but unproven therapy, and if carried out in sufficient numbers, simple studies like this one could identify specific clusters of cancer type, chemotherapy regimen, and high-dose vitamin C in which exceptional responses occur frequently enough to justify appropriately focused large-scale clinical trials [50]
