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The concomitant activation of crypt-associated signalling pathways mobilises neighbouring epithelial cells to temporarily restore the barrier, and, in the long term, allows the proliferation and differentiation of the ISCs to restore the damaged epithelium [37, 38, 82]

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A deficiency can also cause a condition called megaloblastic anemia which creates larger, immature, and abnormal red blood cells and leads to impaired DNA synthesis