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These seemingly contradictory requirements of stability and release lead to the major challenge in the development of linkers

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Ariza, Glazer, and Williams that an abortive lytic process (smoldering EBV infection) is present in many people with ME/CFS may be correct.While it will take more work to determine what these findings mean for ME/CFS, the broad range of dysfunction found and the high rate of active EBV infection (in plasma) would appear to put this pathogen back into play in a meaningful way in ME/CFS.

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