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It is the core citation behind all downstream NNMT-inhibitor drug discovery, including 5-Amino-1MQ — but it used a genetic approach (ASO), not a small-molecule inhibitor, and it was conducted in rodents

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While these symptoms have not been specifically attributed to AOD-9604 excess in published literature, the FDA advises treating any adverse reaction to a compounded product as reportable through MedWatch [8]