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63,65 However, the overall sequence of events leading to cell death after APAP in PHH is very similar to mouse hepatocytes, including GSH depletion, cytosolic and mitochondrial protein adducts formation, JNK activation and translocation to mitochondria, mitochondrial dysfunction, and collapse of the mitochondrial membrane potential preceding cell death (Fig

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doi: 10.1046/j.1359-4117.2003.01096.x