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tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), had decreased from baseline by 8.3%–35% and 22%–28.3%, respectively

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The BMP/Smad pathway effect is counteracted by the transplantation of MSCs derived from bone marrow (BMSCs), which promote NSC differentiation into OLs, the myelinating glia of the CNS (Sandner et al., 2013

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