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Notably, organs with high iron requirements and energy demands, such as the cardiovascular and nervous systems, are particularly affected [69, 70]
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After a therapeutic dose, APAP is mostly converted to pharmacologically inactive glucuronide (APAP-gluc, 52–57% of urinary metabolites) and sulfate (APAP sulfate, 30–44%) conjugates, with a minor fraction being oxidized to a reactive metabolite NAPQI (5–10%) (Figure 1)
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