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This difference matters because it means cagrilintide can suppress appetite through a separate signaling route than GLP-1s, which is exactly why researchers are largely testing it alongside semaglutide, rather than as a replacement for it

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Despite doses of 1,500 mg or 4,500 mg, no significant differences were observed compared to placebo in reducing MDS-UPDRS total scores (Parts I–III) at 52 weeks