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It has been show diminished GSH/GSSG ratios in the kidneys of 8-month-old versus 4-month-old (NZB x NZW) F1 mice, and treatment with N-acetylcysteine (NAC), a precursor of GSH and stimulator of its de novo biosynthesis, prevented decline of GSH/GSSG ratios, reduced autoantibody production and development of glomerulonephritis and prolonged survival of (NZB x NZW) F1 mice [134]