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Here are guidelines for selection: 5-Amino-1MQ will be optimal if: Weight stalled after initial progress on weight loss program There are signs of metabolic dysfunction: insulin resistance, elevated cholesterol Age 35+ and you feel metabolism has "slowed down" Fat tissue is localized in visceral zone (abdomen) You want to maintain NAD+ levels for longevity effects [12] MOTS-c will be optimal if: Low energy and endurance, quick fatigue Impaired glucose tolerance or prediabetes Sedentary lifestyle and physically difficult to start training Age 40+ and want to compensate for age-related decline in endogenous MOTS-c Goal is not only weight loss, but also improving metabolic flexibility [7] Якщо основна проблема — жир не горить (плато ваги) → 5-Amino-1MQ