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This increases the expression of haem oxygenase-1 (HO-1), GSH, and GPX4, eliminates the accumulation of ROS, reduces the levels of lipid peroxide and suppresses ferroptosis (50)

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The mitochondrial [NADH] of 30 μM (Zhao et al., 2011) was found to be roughly 300 times higher than the cytoplasmic [NADH] of 0.1 μM (Zhang et al., 2002), while in cultured HeLa cells the mitochondrial [NADPH] of 37 μM was shown to be only roughly 12-fold larger than the cytoplasmic [NADPH] of 3 μM (Tao et al., 2017)