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Misallocated copper ions generate large amounts of free radicals via Fenton reactions, directly causing oxidative damage and inducing microglial release of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β)

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Figure 5 4 Discussion The widespread application of semen cryopreservation technology has effectively prolonged sperm lifespan, overcoming temporal and geographical constraints while maximizing the preservation of superior genetic resources from elite breeding males