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10.1001/archopht.1978.03910050179015 25 HrelecM.KlicekR.BrcicL.BrcicI.CvjetkoI.SeiwerthS.et al (2009)

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Sometimes we need to also improve GI transit at the smooth muscle level (by utilizing the serotonin precursor 5-HTP for example.) As mentioned, hormones need to be normalized as well