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Drug interaction potential Given that both MDMA and psilocybin modulate serotonin neurotransmission, there is a potential for drug-drug interactions with medications that also modulate the serotonin system, including Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), Tricyclic Antidepressants (TCAs), Monoamine Oxidase Inhibitors (MAOIs), mirtazapine, trazodone, lithium, buspirone, atypical antipsychotics, and others
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