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Furthermore, progestins have been reported to act as anti-inflammatory agents with immunomodulators ( Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) were nuclear receptors that specifically bind retinoic acid (RA) and function as ligand-dependent transcription factors, typically existing as dimers within cells ( In the presented study, transcriptomic and proteomic analyses revealed that RARβ and RXRA were enriched in THRB (−/−) /RL95-2 cells and exhibited significantly higher protein levels compared to those in wild-type RL95-2 cells, and were unaffected by 30 μM MPA treatment