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“Tyrosine Metabolism During Interferon-Alpha Administration: Association with Fatigue and CSF Dopamine Concentrations.” Brain, Behavior, and Immunity , vol

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The mitochondrial inner membrane nicotinamide nucleotide transhydrogenase (NNT) also produces NADPH and this serves to couple reductive stress-induced H 2 O 2 production to NNT-associated NADPH and glutathione redox mechanisms [17]