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and (3) in an attempt to study sertraline metabolite-associated toxicity, we found that sertraline-associated toxicity assessed by ATP depletion and LDH release were enhanced by SKF 525-A, a general inhibitor of CYP 450, indicating that the parent form of sertraline is more toxic than its metabolites

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Funding The authors acknowledge the financial support of the University of Hradec Kralove (Faculty of Science, VT2019-2021) and Excellence project Prf-2206, the University of Hradec Kralove, Hradec Kralove, Czechia