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If there is clinical improvement and if a reticulocyte response is observed, the same amount may be given on alternate days for seven doses, then every 3 to 4 days for another 2 to 3 weeks

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Activation of caspase-4 subsequently activates GSDMD, and the Damage-Associated Molecular Pattern (DAMPs) released can activate the inflammasome (Kayagaki et al., 2015

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