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Metabolism & Elimination The metabolic fate and degradation pathways of MOTS-c remain incompletely characterized, representing a significant gap in pharmacokinetic understanding: Rapid plasma clearance observed in preclinical models, though precise half-life not definitively established Likely degradation through peptidase activity, though specific enzymes not identified No accumulation detected in chronic administration studies (animal models) Active metabolites not characterized
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doi: 10.3892/mmr.2011.645
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