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It is reported that neuropeptides like PACAP and CGRP stimulate T cells, macrophages, and mast cells to initiate or amplify the inflammatory response, which is called neurogenetic inflammation (47)
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For example, the silent information regulator 1 (SIRT1), a NAD + -dependent protein deacetylase, functions as a key upstream regulator for LKB1/AMPK signaling in the liver 50
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