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Because acute liver failure was poorly studied and understood, centralized data registries, such as the United States Acute Liver Failure Study Group, were formed to improve detection and patient outcomes
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Interestingly, radiosensitization of nasopharyngeal carcinoma cells by inhibition of glutamine synthetase showed that this radiosensitization was dependent on the activity of de novo pyrimidine and purine synthesis, with glutamine synthetase-knockdown cells demonstrating significantly lower levels of homologous recombination, implying that a significant portion of nucleotide synthesis in irradiated cells is dependent on glutamine metabolism 211
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