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MATERIALS AND METHODS Formalin-induced nociceptive behavioral test The time-effect curves of the control, morphine, and BPC-157 (from 10 to 40 μg/kg) groups for the flinching response in the formalin test are shown in Figure 1

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For male mice, there were significant increases in alternation percentages in transgenic male mice treated with intranasal GHK-Cu compared to transgenic male mice treated with intranasal saline starting the first month and continuing for the next 2 months of the study (Figure 1B)