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, NLR family pyrin domain containing 3 (NLRP3)) that sense pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), such as the accumulation of ROS or the efflux of potassium ions (K + )
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By modulating the harmful effects of senescence, these therapies could slow down or even reverse conditions such as neurodegenerative diseases (eg, Alzheimer’s, Parkinson’s), cardiovascular disease, arthritis, and metabolic disorders (eg, type 2 diabetes).193 Since many of these diseases are associated with the accumulation of senescent cells and their inflammatory secretions, senomorphic compounds have the potential to treat the root cause of these diseases, rather than just alleviating symptoms.201 Personalized Medicine Approaches: As our understanding of individual aging profiles and senescence mechanisms deepens, there is an opportunity to design personalized treatments based on a person’s genetic makeup, lifestyle factors, and specific senescence-related conditions
