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Among the most frequently reported adverse effects are minor and self-limiting such as local injection site erythema, transient hormonal shifts, and receptor desensitization with prolonged or high-frequency use

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Notably, HSBP7 is particularly effective against long polyQ repeats (119Q), whereas HSBP6, HSBP8, and HSBP9 preferentially counteract shorter polyQ expansions (43Q), indicating substrate-length specificity within the sHSP family