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GHK has a higher affinity for Cu²⁺ than serum albumin does, so it effectively pulls copper off albumin and hands it to cellular copper chaperones and cuproenzymes — lysyl oxidase, superoxide dismutase, cytochrome c oxidase — that run ECM crosslinking, redox defense, and mitochondrial respiration

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However, while these studies show promising results, further research is needed to better understand the optimal extraction methods, concentrations, and application techniques for maximizing efficacy