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For example, in colorectal cancer, elevated lactate levels induce H3K18 lactylation and direct lactylation of methyltransferase-like 3 (METTL3) at RNA-binding zinc-finger domains, enhancing its ability to catalyze m⁶A modification of JAK1 mRNA
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Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells
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