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119 During acute liver failure, interleukin 1 receptor type 1 (IL-1R1) is stimulated by IL-1 and activates the NF-κB signaling, which promotes transcriptional upregulation of inflammation-related genes and recruitment of immune cells, while NF-κB inhibits TNF-activated JNK/ERK signaling and prevents caspase 3-mediated apoptosis, which further amplifies inflammatory responses and exacerbates hepatic injury

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