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Key challenges include unresolved long-term biosafety profiles, the absence of standardized large-scale manufacturing protocols, and the insufficient investigation into their potential effects on autophagy and ferroptosis in normal tissues

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Without a preservative, though, it offers no protection against microbial growth once the vial has been accessed, which is why solutions reconstituted with sterile water carry a meaningfully shorter usable window than those prepared with bacteriostatic water