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3-D elemental bioimaging, which has revealed elevated levels of Mn in the anterior pretectal nucleus, deep mesencephalic nucleus, and medial geniculate nucleus in a Parkinson’s disease model, also showed a high concentration of Mn in the region of the needle track where brain tissue was lesioned by injection of the neurotoxin 6-hydroxydopamine, suggesting that trauma may also lead to alterations in Mn distribution (127)
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