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Mast cells can regulate peristalsis and fluid secretion via bidirectional brain-gut interactions between the ENS and the CNS (Schaeffer et al., 2012)

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suggests that TB-500 may interact with cell movement as it binds globular actin (G-actin) and may modulate how actin filaments assemble to plausibly make endothelial cells more able to change shape, migrate, and form multicellular structures