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Therefore, it is crucial to prevent heart complications in advance at the preclinical phase of the disease [52,53]

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The potential mechanism of targeted harmful effects of N,N -Dimethylformamide on liver was mainly contributed to oxidative stress caused by reduced GSH level and increased reactive oxygen species ( N,N -Dimethylformamide involved the activation of NLRP3 inflammasome ( N,N -Dimethylformamide and ethylbenzene, styrene also cause RA, since excessive oxidative stress and inflammatory reaction are also the main mechanism of RA ( In conclusion, we identified several VOC was significantly associated with RA, through analyzing the association between the VOCs in urine and RA