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Induction of the mitochondrial enzyme aldehyde dehydrogenase 2 (ALDH2) by Alda-1 resulted in the reduction of 4HNE formation, attenuated the MPTP opening, and reduced liver injury after an APAP overdose [86]

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In the oral cavity, a unique feature to be handled by the host defence is that continuously replaced bacteria may obtain a firm anchorage on the nonshedding tooth surface and will thereby remain in close contact with the soft tissues surrounding the tooth for a long time and evoke inflammation (1, 2)