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Nausea (most common, typically dose-dependent and transient) Diarrhea or constipation during dose escalation Vomiting, especially when starting or increasing dose Reduced appetite and early satiety Injection site reactions (redness, bruising) Fatigue, particularly in early weeks Rare: Pancreatitis — discontinue immediately with severe abdominal pain Rare: Thyroid C-cell effects (contraindicated with MEN2 or thyroid cancer history) AOD-9604 is a modified C-terminal fragment (residues 176–191, Tyr-hGH177-191) of human growth hormone, studied for lipolytic and anti-obesity properties

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Dans les modèles précliniques, l’inhibition de la NNMT a été associée à des variations du 1-méthylnicotinamide intracellulaire, du NAD+, de la S-adénosylméthionine, de la lipogenèse, du tissu adipeux et du métabolisme énergétique [2]