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The ability of any gene to have this effect is the basis for an overexpression screen to select such key genes

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Conversely, individuals with mutations undermining the generation of PE phospholipids present with severe hereditary spastic paraplegias and white matter pathology, as seen with loss-of-function mutations in SELENOI 166 , 167 and PCYT2 , 168 which are necessary for de novo synthesis of PE phospholipids (Figure 4E)

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