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This process is associated with morphological alterations typical for apoptosis, like cell shrinkage, membrane blebbing, and phosphatidylserine (PS) translocation to the outer leaflet of the cell membrane phospholipid bilayer [22, 23]

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L-DOPA, an amino acid precursor of dopamine that can cross the blood-brain barrier, is changed into dopamine in the presynaptic terminals of dopaminergic neurons by the enzyme aromatic amino acid decarboxylase (AADC)