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Synthetic HNPs function as histone-chelating agents through selective neutralization of circulating histones (key DAMPs causing endothelial dysfunction), peripheral sequestration of histones to inhibit platelet aggregation, and attenuation of pulmonary leukocyte migration, collectively improving outcomes in experimental sepsis models [94]

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Furthermore, post hoc analyses suggested a lower incidence of eczema and atopic dermatitis in the synbiotic group, although further research is needed to establish direct clinical benefits [121]